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KMID : 0878220100220030141
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Journal of Sasang Constitutional Medicine
2010 Volume.22 No. 3 p.141 ~ p.151
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Stimulation of the Immune Response by Herbal Formulas for Taeeumin
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Jung Da-Young
Ha Hye-Kyung
Lee Ho-Young
Lee Jin-Ah
Lee Nam-Hun
Lee Jun-Kyoung
Huang Dae-Sun
Shin Hyeun-Kyoo
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Abstract
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Objectives: Three herbal formulas (Yuldahanso-tang, Chungsimyonja-tang, and Taeeumjowi-tang) for Taeeumin were applied to investigate the immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in murine macrophage cell line (RAW 264.7) and ovalbumin (OVA)-immunized mice.
Methods: This study was carried out in nitric oxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes according to three herbal formulas. C57BL/6 mice were immunized intraperitonially with OVA/aluminium (/mouse) on day 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured.
Results: Yuldahanso-tang and Chungsimyonja-tang increased NO synthesis in RAW 264.7 cells. Three herbal formulas significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<.001). Three herbal formulas for Taeeumin also significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group.
Conclusion: These results suggested that three herbal formulas for Taeeumin could be used as stimulator of immune response.
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KEYWORD
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Yuldahanso-tang (Reduohanshao-tang), Chungsimyonja-tang (Qingxinlianzi-tang), Taeeumjowi-tang (Taiyintiaoweitang), Immune response
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